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Moreover, in many cases, the administration of these drugs over a long period is not very effective, and it often leads to the recurrence of the disease (Melo et al

151,152 GDH1 depletion results in imbalanced redox homeostasis and cell cytotoxicity and attenuates cancer cell proliferation, which as well as the results in erythroleukemia cells, while it negligibly affects normal cell proliferation

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Repeated cycles compound the damage

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