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Patients with pre-existing migraines, poor fluid intake, or polycystic ovary syndrome may report higher headache frequency during dose initiation

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First-line treatments for anxiety in the UK, according to NICE guidelines, include psychological therapies such as cognitive behavioural therapy (CBT), which has strong evidence for effectiveness in generalised anxiety disorder, panic disorder, and social anxiety disorder

The effect of TZDs on insulin sensitivity is mediated by the activation of PPAR, a nuclear receptor that regulates the transcriptions of several genes involved in glucose and lipid metabolism and energy balance and increases fat oxidation, adipocyte proliferation, lipogenesis, fat redistribution, and reduces plasma free fatty acid and pro-inflammatory cytokine levels [159]

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