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Abstract In the mouth, melanin is produced by melanocytes residing in the basal cell layer of the oral epithelium

The identification of exendin-4 from Gila monster (Heloderma suspectum) saliva as a stable GLP-1 mimetic enabled appetite suppression and glycemic control in metabolic disease, driving the development of long-acting GLP-1 analogues and unimolecular agents that co-activate GLP-1 and GIP receptors (Mller et al., 2025)

Prof Sievenpiper: Our lab was interested in the impact of caloric sugars on health through their metabolic effects and their effects on hormones

Drug Metab Dispos (2015) 43(10):155771

The Rise of GLP-1 Drugs Because of the hormones powerful effects on appetite and glucose metabolism, researchers began exploring whether GLP-1 drugs could replicate or amplify these natural signals