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Other studies have been performed to unravel the mode of action (MoA) of OTA, for example, to determine if it acts by a DNA-reactive MoA (resulting in mutagenicity) or whether perturbations of other critical cellular processes may explain the non-linear dose response observed in organ- and site-specific tumor development (Mally 2012
Extended data figures and tables Extended Data Fig
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This release subsequently activates the caspase cascade pathway, culminating in apoptosis [97]
The process can also optionally involve adding a base to salify the GSH before spray-drying
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