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Accessed 7/2/18

Pituitary hCG or trophoblastic disease can cause this

Beyond clinical kidney benefits, CVOT and kidney outcome trials have consistently demonstrated benefits on HF outcomes, leading to dedicated HF outcome trials

Many patients do not reach higher maintenance doses (10 mg, 12.5 mg, or 15 mg) until 16-24 weeks into treatment

Symptomatic NCM occurs in approximately 4% of patients with a high-risk CMN, with onset of clinical manifestations (eg, hydrocephalus and seizures) at a median age of 2 years and a poor prognosis even in the absence of malignancy

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