The current study encompassed all cases in which GLP-1RAs were administered and listed as primary suspect drugs, secondary suspect drugs, or concomitant drugs for SSIBs
Saxenda comes in five dose strengths : 0.6 mg, 1.2 mg, 1.8 mg, 2.4 mg, and 3 mg

Study Population : 1,961 adults without diabetes Average age: 46 years Average baseline BMI: 37.9 Average baseline weight: 231.3 pounds 74.1% female, 25.9% male 76.6% White, 11.6% Black, 7.0% Asian, 4.8% Other Intervention : Semaglutide 2.4 mg subcutaneously once weekly (n=1,306) Placebo subcutaneously once weekly (n=655) Both groups: Individual counseling sessions every 4 weeks promoting 500-calorie deficit and 150 minutes/week physical activity Duration : 68 weeks Primary Outcome - Mean Percentage Weight Loss : Semaglutide: -14.9% (95% CI: -15.3 to -14.5) Placebo: -2.4% (95% CI: -3.0 to -1.8) Difference: -12.4 percentage points (p0.001) Secondary Outcomes - Categorical Weight Loss : 5% weight loss : 86.4% semaglutide vs 31.5% placebo 10% weight loss : 69.1% semaglutide vs 12.0% placebo 15% weight loss : 50.5% semaglutide vs 4.9% placebo 20% weight loss : 32.0% semaglutide vs 1.7% placebo Trial Completion Rates : Semaglutide: 81.7% completed 68 weeks Placebo: 82.0% completed 68 weeks High completion rates suggest good tolerability and participant satisfaction Safety Data : Gastrointestinal adverse events: 74.2% semaglutide vs 47.9% placebo Serious adverse events: 9.8% semaglutide vs 6.4% placebo Discontinuation due to adverse events: 7.0% semaglutide vs 3.1% placebo STEP 2: Diabetes Population Trial Citation : Davies M, et al

Cost per mg is given so researchers can compare vial sizes on a like-for-like basis
Research also suggests that by facilitating weight loss, GLP-1 medication can indirectly reduce the burden on your other systemshelping to improve symptoms of PCOS, knee osteoporosis, sleep Apnea and even substance use disorders
The muscle loss is not due to direct drug toxicity but rather to the metabolic consequences of significant caloric restriction