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Another practical consideration is cost

Another study showed that mice with a keratinocyte-specific deficiency in mitochondrial transcription factor A (TFAM), a gene required for the transcription of mitochondrial genes, have abnormalities in hair follicle growth, and that mitochondria-generated ROS was in fact necessary for the mediation of cell differentiation 95

It is a heterogeneous disease that is further classified into different molecular subtypes based on gene expression profiling (Polyak, 2007)