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Alcohol preoccupation/anticipation may lead to relapse which can be studied in animals by assessing drug- and cue-induced reinstatement (Sanchis-Segura and Spanagel, 2006)

Next to indole, which acts on voltage-gated K + channels to enhance Ca 2+ entry thereby stimulating GLP-1 secretion (36) and microbiota-derived SCFA that are sensed by FFAR2/GPR43 and FFAR3/GPR41 (see above), the importance of bile acid-induced incretin secretion via the bile acid receptor GPBAR/TGR5 has been proven in vitro and in vivo

2 decision to remove the medicine from a national drug shortage list

All data are presented as mean s.e.m

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Weight loss typically continues at a slower rate, and appetite suppression remains effective even if it feels less dramatic