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Psychological factors , including stress, anxiety, depression, and emotional eating patterns, can also drive hunger independently of physiological satiety signals

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Variation in insulin response following bolus administration of glucose in metabolically healthy individuals or patients with type 2 diabetes

Additionally, the T149M variant is associated with increased T2D risk and has normal surface expression but reduced binding affinity for GLP-1 and Exenatide, as well as reduced cAMP production (Suzuki et al., 2019)

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