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Beyond triple agonism

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Food and Drug Administration, FDA, 8 Nov

Jayne Hornung, chief clinical officer at Managed Markets Insight and Technology, suggests initial pricing of oral GLP-1s for weight loss could be reminiscent of the early days of anti-CGRP medications for migraines when the first oral CGRP came to market in 2019, the pricing still remained high

Compounding pharmacies may face restrictions similar to what happened with compounded semaglutide when Ozempic faced shortage declarations and subsequent regulatory scrutiny

But the actual outcome of combining a daily GHRH analog with a weekly triple-receptor agonist in a living human body remains entirely unknown