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Results were dose-dependent, with lower doses producing more modest reductions

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Epigenetic regulation plays a pivotal role in the pathogenesis of DKD, providing a molecular basis for the phenomenon of metabolic memorywhereby transient episodes of hyperglycemia induce long-lasting pathological changes in renal cells (64, 65)

10.1056/NEJMra1004965 36 MeiL.YangZ.ZhangX.LiuZ.WangM.WuX.et al (2021)

Sufficient insulin secretion maintains low levels of KBs by inhibiting the expression of hormone-sensitive lipase (144)

Table 3 a Calculated from the original authors' fitting equation over the range of their experimental values