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These hormonal shifts cause the prostate gland to gradually enlarge, which can press against the urethra and lead to common urinary symptoms such as difficulty starting to urinate or needing to go more frequently.h BPH itself typically does not affect a mans life expectancy, as its a noncancerous enlargement of the prostate that mainly causes urinary symptoms

Absolute numbers of individuals with each outcome of interest are presented in ESM Table 1

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