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At higher supplemental doses (500 to 3000 mg daily), niacinamide can cause nausea, liver enzyme elevation, or glucose intolerance, but these effects are unlikely at the low doses used in compounded formulations

Therefore, it is in this context that inhibiting the activity of GSTs has the potential to be used as a therapeutic strategy to reverse MDR (Ban et al

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Once submitted, the FDA has 60 days to accept the application and assign a PDUFA date, after which the 610 month review period begins

After a switch, increase no faster than every 4 weeks, and only if current goals arent met and side effects are acceptable

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