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Family history of breast cancer Among risk factors for breast cancer, family history seems to be the strongest risk, with almost 20% of all breast cancers having a family origin and are dependent in an etiological fashion on a specific predisposing gene of that disease ( BRCA1 ) and Breast Cancer gene 2 ( BRCA2 ), located on chromosomes 17 and 13, respectively, account for many high-risk families

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Main text Methodology Two groups of investigators were working independently for the study selection

Stress or poor health can block these signals

2) Activation of endothelial cells and disruption of tight junction proteins within the neurovascular unit may result in persistent dysfunction of the BBB (129)