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Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling

Researchers believe the cause is multifactorial due to inhibition of tyrosine and tryptophan hydroxylase, increased oxidative stress, altered lipid metabolism, and myelin sheath production.[ref] BH4 (as sapropterin) is used as a drug to treat phenylketonuria

A treatable target

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Guo et al., Leptin signaling targets TRH gene promoter in vivo, Endocrinology, 2004