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GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine

The microdose program typically starts at a very low dose of 0.2 mg per week , with the ability to adjust up to a maximum of 0.6 mg if needed

Previously, people who were taking smaller doses of GLP-1s were either getting them off label from a physician which means they were prescribed, but not based on the protocols approved by the FDA or getting them illegally online and figuring out how to take them on their own

This was pretty bad because I spent a good amount of time fighting myself to get work done

Retatrutide activates GLP-1 receptors in the brain, specifically in the hypothalamus, which directly reduces hunger signaling

Hinyokika Kiyo (1995) 41(1):515