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Lancet (2025) 406(10520):2685702

Since B12 is water-soluble, meaning your body easily pushes out any extra through urine once youve absorbed what you need, there is no concern of overdosing on B12

Preclinical Research: Animal studies have demonstrated that GLP-1 agonists can reduce drug-seeking behavior in rodent models of cocaine and opioid addiction

Delayed gastric emptying occurs when food remains in the stomach for more than 4 hours, compared to the normal 1.5-2 hours, causing fermentation and bacterial overgrowth