Moreover, it deactivates tyrosinase, preventing excess pigment formation
44 Although the cells at the base are smaller, they show atypical features including conspicuous nucleolation, nuclear membrane irregularity, hyperchromasia, increased nuclear-to-cytoplasmic ratios, and mitotic activity, all of which are unusual in the banal common acquired nevus (Figures 14 and 15)
10.1038/s41598-020-57467-z Sci
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However, measuring cytotoxicity alone is not sufficient
As with the estimated allowed amount in the current rule, and as we explained in the CY 2024 OPPS/ASC final rule with comment period (88 FR 82101), the amount should reflect the total amount the hospital was reimbursed for the item or service (or service package)