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N Engl J Med (2007) 356(3):2135.10.1056/NEJMp068177 3 SartorRB

Beyond sleep, Ive noticed improved recovery from physical activity and a general sense of resiliencethat quality of being able to handle stress, whether physical or emotional, without becoming depleted

This pathway also supports cell survival and proliferation, helping maintain sufficient cell mass to sustain normal insulin output

The people who dropped out because of side effects seem to have disappeared from the final tally of adverse reactions

The titration schedule begins at 2.5 mg weekly for 4 weeks, then escalates through 5 mg, 7.5 mg, 10 mg, and 12.5 mg at 4-week intervals as tolerated, up to a maximum maintenance dose of 15 mg