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This group of vitamins are known as cobalamins, are water soluble (1, 2)

Since it is able to cross the blood-brain barrier, this form of carnitine is increasingly found in brain cells, where it can have a positive effect on brain functions

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Although the steric bulk of the (CH 2 )3 side chain might diminish activity relative to the natural GLP-1R agonists, these replacements should test the hypothesis that GLP-1R agonist activity is higher for ligands that can access non-helical conformations near the N-terminus, compared to those that cannot