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Pathophysiological mechanisms Gastrointestinal surgery produces alterations in the regulation of hydrocarbon metabolism, creating conditions that favour PHH6,7 among which the following stand out (Fig

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Adopting a holistic approach that includes dietary modifications, regular physical activity, and behavioral adjustments can enhance the results of pharmacological interventions and promote long-term weight management

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GLP-1 receptor agonist medications (including semaglutide, dulaglutide, liraglutide, exenatide, and lixisenatide) are typically considered for type 2 diabetes when: Triple therapy with other diabetes medications is not effective, not tolerated, or contraindicated The person has a BMI 35 kg/m (adjusted by 2.5 kg/m for people from South Asian, Chinese, other Asian, Black African, or African-Caribbean backgrounds) and specific weight-related psychological or medical problems A lower BMI threshold may be appropriate if weight loss would benefit other obesity-related comorbidities Insulin would not be appropriate or acceptable to the person Treatment is usually continued only if there is a beneficial metabolic response (reduction in HbA1c and weight) after 6 months