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Mice with impaired polymerase- proofreading ability show rapid accumulation of mtDNA mutations leading to disrupted mitochondrial function, a variety of aging phenotypes and early death (Trifunovic et al., 2004)

363 MDM2 inhibition and wild-type p53 activation, which involves the activation of p53-targeted genes, including CDKN1A, BBC3, and Bax, and the induction of apoptosis, have beneficial effects on refractory/relapsed (R/R) AML and chronic myeloid leukemia (CML) patients

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Nevertheless, there comes a stage when the hair follicle loses its connection to the tiny skin muscles known as arrector pili muscles

B12 is also essential for maintaining normal brain function and contributing to the psychological health of an individual

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