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For dosage information, we found that 58.4% of semaglutide users and 64.3% of tirzepatide users self-reported a dosage equal to that recorded in the EHR

In a 48-week phase II clinical trial conducted on patients with type 2 diabetes and obesity, treatment with a dose of 10 mg/kg of bimagrumab resulted in a significant reduction in fat mass by 20.5% (compared to 0.5% in the placebo group), while lean body mass increased by 3.6% (as opposed to a decrease of 0.8% in the placebo group), leading to an overall body weight reduction of -6.5%, which was substantially better than the -0.8% observed in the placebo group

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Still, a supplement is not a drug

A more recent study highlights how GPR42 is not only functional, but displays a pool of haplotypes in a great proportion of humans, with a distinct pharmacology (313)

Ginger tea specifically has evidence supporting its anti-nausea effects and can be a useful tool during dose transitions