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10058-F4 promotes an increase in the expression of thioredoxin-interacting protein in triple-negative breast cancer drug-resistant cells, which enhances reactive oxygen species synthesis and reverses doxorubicin-induced chemotherapy resistance [43]

ROS produced by TAMs can activate MDSCs, leading to further production of ROS and other inhibitory molecules, creating a positive feedback loop that exacerbates T cell dysfunction [46]

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