Zebrafish-based small molecule discovery
Weight loss from GLP-1 medications independently improves insulin sensitivity and reduces the metabolic stress on beta cells
Emerging research also suggests that these skin changes may also be related to a depletion of cells that contribute to collagen production
The future of semaglutide and similar agents looks promising, with ongoing research exploring additional therapeutic applications and long-term benefits
This limitation is, however, mitigated by the recent findings of Lamont et al [8] who, using transgenic overexpression of Glp1r in beta cells of Glp1r- null mice, clearly established the critical role of the beta cell GLP-1 receptor (GLP1R) in mediating the beneficial effects of GLP-1 on glucose homeostasis
287 , 36423658 (2012) Wood, V