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Gastrointestinal event rates were 80% with the combination, 73% with semaglutide alone, 60% with zalfermin alone, and 51% with placebo, while serious adverse event rates were 7%, 10%, 13%, and 5%, respectively

The long-term side effects of semaglutide are less common but can be more serious

Since this is a nasal spray designed for precision dosing, researchers often want to know whether the compound maintains consistency across multiple administrations

Rescue medication was provided to nine patients (3.1%) in the semaglutide 0.5 mg group, four patients (1.4%) in the semaglutide 1.0 mg group and 19 patients (6.6%) in the sitagliptin group

But after it's opened, compounded semaglutide only lasts in the fridge for 28 days

It also stays in the body longer than the other forms, so does not need to be taken as often and doesn't have the peaks and dips of other forms