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Rathbone JA, Cruwys T, Jetten J, Banas K, Smyth L, Murray K

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Less Frequent Dosing: Because transdermal patches provide a sustained release of medication, they often require less frequent dosing than oral medications, which can improve patient convenience and compliance

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For patients who discontinued treatment during the study period, we used the day of treatment discontinuation (defined as the estimated end date of the most recent prescription plus the grace period of 90 days) as the start of follow-up to assess treatment reinitiation, defined as the first new prescription of the drug class that had previously been discontinued

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