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Given the fact that APAP toxicity is initiated by metabolism through cytochrome P450 enzymes, any subtle interference with the formation of reactive metabolite NAPQI and accumulation of APAP protein adducts (APAP-ADs) can produce a profound impact on the outcome of APAP-induced liver injury

C.Snchez-CalvoB.ChakiM.Mata-PrezC.ValderramaR.PadillaM

17 Similar findings have been reported in analyses of subjects who underwent metabolic surgery compared with those who did not

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enhancing absorption of vitamins C and E

Sci Rep 6:117