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Knudsen N, Jorgensen L, Hansen J, Vermehren C, Frokjaer S, Foged C

Tricyclic Antidepressants (TCAs): The Interaction with Cannabis TCAs, such as amitriptyline (Elavil) and nortriptyline (Pamelor), increase serotonin and norepinephrine levels similar to SNRIs

They majorly show significant improvements in blood glucose, both fasting and in response to a glucose tolerance test [13]

Medically reviewed by Alan Lucks | MD , Alan Lucks MDPC Private Practice - New York on December 19th, 2025