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Exceeding anatomical volume limits causes tissue distension, localized pain, and unpredictable absorption as the injected fluid pools rather than diffuses

Concurrently, semaglutide normalized the balance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), leading to increased MMP-2 and MMP-9 activity and reduced TIMP-1 levels, changes indicative of enhanced ECM remodeling and decreased matrix accumulation [55]

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