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Reference lists of included articles and relevant reviews were manually screened to identify additional pertinent studies

Patients in whom heart failure (HF) or chronic kidney disease (CKD) is prevalent, should receive a treatment intensification with an SGLT-2 inhibitor with the respective evidence from clinical studies due to the respective data (7072)

This overproduction can be triggered by UV exposure, inflammation, and hormonal changes all processes worsened by oxidative damage

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Similar content being viewed by others Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in progressive weakness and selective degeneration of the motor neurons, leading to death from respiratory failure within 34 years [1]

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