Start retinol slowly two to three nights per week and allow the skin to build tolerance before using both on the same night
doi: 10.1095/biolreprod64.2.674, 139
For general wellness, monthly injections are typically sufficient
Makowski (2021) also noted that diets high in saturated fats and sugars correlate with elevated sleep-related impairment scores [139]
Key risks of unsupervised use include: Gastrointestinal adverse effects : Nausea, vomiting, and diarrhoea can be severe, leading to dehydration, electrolyte imbalance, and nutritional deficiencies, particularly if dose escalation is too rapid or dietary intake is inadequate
What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: an update