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Activation of NF-B induces the expression of pro-inflammatory cytokines like TNF-, IL-1, and IL-6

Sterile technique during reconstitution determines contamination risk, which shortens usable life further

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2017;12(9): e0184843

To reduce irritation and lumps, it helps to rotate injection sites (dont inject the same spot repeatedly), inject into healthy skin (avoid bruised, scarred, inflamed, or irritated areas), and keep your routine consistent (many protocols are taken in the morning)

doi:10.1093/qjmed/95.9.559 [36] Lonsdale D