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Conducted in artificial cell lines, the findings did not address the key question as to whether the truncated form of GLP-1 located in the gut activated the pancreas to release insulin in the way incretin was presumed to work

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Tirzepatide induced larger reductions in body weight vs GLP-1 RAs, ranging from 1.68 kg (95% CI 0.84, 2.52 [ I 2 0%]) with tirzepatide 5 mg to 7.16 kg (95% CI 4.86, 9.46 [ I 2 72%]) with tirzepatide 15 mg (Fig

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