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The gene is transcribed into two alternatively spliced mRNAs that encode proCART peptides of different lengths identified as proCART1-89 and proCART1-102

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Combination therapy is typically considered when monotherapy or dual therapy with other agents (such as metformin) fails to achieve adequate glycaemic targets, or when patients require additional cardiovascular or renal protection

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Similarly, the AMPK Blend provides additional upstream AMPK activation through plant-derived compounds that complement MOTS-c's intracellular mechanism