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Emerging evidence has further demonstrated that exosomal Trx1 derived from hypoxic human stem cells activates mTOR complex 1 (mTORC1) signaling upon cellular internalization, exhibiting anti-ferroptotic and cardioprotective effects against doxorubicin-induced cardiotoxicity (84)

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A single injection of double-stranded adeno-associated viral vector expressing GH normalizes growth in GH-deficient mice

10.1016/j.jad.2020.05.026 5 ChenY.LiS.ZhaoJ.CaoX.WangF

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Liver damage: Although not common, some reported cases of liver toxicity are associated with high-dose glutathione injections, particularly in individuals with underlying liver disease or those taking medications that can affect liver function