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The use of legumes is also regarded as a means of alkalinity management and has been applied in various parts of the world, as they have an inherent ability to acidify the soil
Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1/VEGF axis
However, a notable side effect was observed: MT-II-treated normal C57BL/6J mice exhibited significant weight loss, with their average weight decreasing from a baseline of 30.9 1.4 grams to 26.5 1.7 grams after the 14-day treatment course, a change not seen in vehicle-treated controls
Additionally, it led to a cell cycle arrest at the G0/G1 phase and a reduction in the number of cells in the S phase
doi:10.1021/acs.jproteome.3c00646 Tabb DL, McDonald WH, Yates JR