how long have glp 1 meds been around GLP-1 Drugs and Type Diabetes: Less Insulin, Better Time in Range — What the Evidence Upgrading from Overweight: The Effects

Dludla et al., 2018)

Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice

In rodent models, GLP-1 also enhances modest beta cell mitogenesis and inhibits apoptosis thereby leading to enhanced beta cell mass (13, 107, 135)

Bismuth subsalicylate (Pepto-Bismol)

Older adults usually get the same dose as younger people, but need more watching for side effects

The SUSTAIN-6 Trial (Once-Weekly Semaglutide) The Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) consisted of 3297 people living with T2DM, 83% with established cardiovascular disease, receiving once-weekly semaglutide (0.5 and 1.0 mg) or placebo