At 100 mg/mL, 1 unit = 1 mg
Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls
Starting low and titrating up remains the safest approach
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And in the 80s it increased to every three months, which is still what they use today
They can adjust the dosage based on the individual's response and ensure safe administration