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The DHE staining results also showed that FOXO4-DRI can effectively reduce the production of ROS in the vessels of aging mice (Figure 1F)

In its reduced state, it can donate electrons to neutralize reactive oxygen species (ROS) and other free radicalshelping prevent oxidative damage to lipids, proteins, and cellular membranes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Tsamesidis I., Reybier K., Marchetti G., Pau M.C., Virdis P., Fozza C., Nepveu F., Low P.S., Turrini F.M., Pantaleo A

Following the evaluation inside two-dimensional monolayer cancer cells, the therapeutic properties were studied in three-dimensional multicellular tumor spheroids

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