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Acknowledgements This research was funded by the Guangdong Provincial Department of Education as a scientific research project (2024KQNCX133), Zhanjiang Marine Youth Talent Project (2024R3004), the National Natural Science Foundation of China (82103834) and the Innovative Research Group of Functional Food Development and Quality Analysis (ZY24PYTD05)

All were randomly assigned to receive semaglutide (1mg) or placebo for one year (52 weeks)