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What causes this decline

The viability and good health of naive GCLM knockout mice makes them a valuable model for studying the impact of chronic GSH deficiency 18

Longer exposure, combined with full-dose maintenance after titration, produces substantially deeper weight loss

Kidney function biomarkers including creatinine clearance and urea levels showed normalization toward younger reference values, indicating restoration of tissue homeostasis

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J Biol Chem 284:2245722466 Sontheimer H (2008) A role for glutamate in growth and invasion of primary brain tumors