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This review ultimately incorporated 19 studies, comprising prospective observational studies, large-scale retrospective cohorts, active-comparator new-user cohort designs, and multiple randomized controlled trials (RCTs)

In glioblastoma (GBM), AMPK-HIF-1 signaling reinforces glucose-derived de novo serine synthesis to facilitate tumor growth (100)

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Ethics declarations Competing interests All authors declare no competing interests

Cysteine residues pose a similar challenge