Independent pharmacokinetic comparison studies are limited
GLP-1 receptor activation slows gastric emptying, which can cause variable bowel changes including looser stools, diarrhoea, or constipation
Despite headline-grabbing clinical results (up to 22% weight loss in trials), studies show average weight reduction in routine care is typically 28% after a year, with only about one third of patients achieving greater than 5% loss
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