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Published preclinical and in vitro research has examined its interaction with extracellular matrix remodelling, broad gene-expression modulation, antioxidant and anti-inflammatory pathways, and copper-coordination chemistry in cultured fibroblasts and animal wound models

Rats treated with 10 mcg/kg showed 6080% reduction in ulcer area at 14 days compared to untreated controls

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Biochemical signs include more stable serum estradiol and progesterone profiles, normalized gonadotropin levels, and lower inflammatory markers like C-reactive protein

Contraindications and clinical precautions include: Medullary thyroid carcinoma (MTC): Cagrilintide is contraindicated in individuals with a personal or family history of MTC due to its structural similarity to calcitonin, which may theoretically influence C-cell activity