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A rough rule: if your scale weight is dropping faster than 1 percent of body weight per week over multiple weeks, investigate whether protein intake and training volume are adequate before concluding that faster is better

Protocols should only be conducted in properly equipped laboratory environments by qualified researchers

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Current clinical studies have focused on adults living with obesity, as well as adults who are overweight and have additional weightrelated health conditions

Randomized controlled trials (RCTs), which is the gold-standard approach to extend indication of marketed drugs, have been limited by short follow-up periods and insufficient number of cases to detect the effect of GLP-1R agonists on ovarian cancer 15,16,17

205 Currently, three major categories of SIRT1-targeted drug candidates are under investigation: natural products, synthetic small-molecule activators, and NAD + precursor supplements