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It binds to GHRH receptors on pituitary somatotroph cells, stimulating the synthesis and secretion of endogenous growth hormone in a natural pulsatile pattern (1)

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doi: 10.1016/j.jemrpt.2025.100139 14 SoodNBansalOGargRHoskoteA

Ruvolo PP, R-Y W, Ruvolo VR, Jacamo R, McQueen T, Borthakur G, Qiu YH, Kevin R Coombes KR, Zhang N, Shpall EJ, Champlin RE, Garzon R, Marcucci G, Croce CM, Konopleva M, Andreeff M , Kornblau SM

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Palmitoyl tripeptide, also known as Pal-GHK, is a man-made peptide that is intended to improve skin health, decrease pigmentation, and enhance collagen formation