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Interestingly, a subgroup analysis of the Thiazolidinediones Or Sulfonylureas Cardiovascular Accidents Intervention Trial (TOSCA.IT) suggested that even low doses of PIO can significantly improve liver steatosis and inflammation in patients with T2D independently of its blood glucose lowering effect [54]

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These findings suggest that the microbiome may contribute to the pathogenesis of depression through complex interactions involving microbial metabolites, neurotransmitter regulation, and immune system modulation

It is used as a skin-lightening agent in concentrations of one to four per cent