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Evaluating effective permeability coefficient P eff using in situ single-pass intestinal perfusion (SPIP) models eff in situ single-pass intestinal perfusion (SPIP) models Among the FDA-approved methods for assessing permeability, rat intestinal perfusion studies have proven to be a reliable and physiologically relevant method for permeability measurement and BCS classification [6]

Moreover, this study revealed not only heat stress-induced alterations in mitochondrial distribution 57 but also a trend in which homogeneous mitochondrial distribution aligns with the mitochondrial membrane potential during summer

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

It has been widely used in preclinical therapy for tumors, intestinal diseases, and anemia via oral administration 20,21,22

[Google Scholar] 13.Nordlund JJ, Boissy RE

The absence of clinical trials means long-term effects, drug interactions, and organ-specific toxicity remain unknown