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Abstract The uncoupling of Mitochondria-ER Contact Sites (MERCS) represents a hallmark of metabolic dysfunction in obesity and type 2 diabetes

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Central Nervous System Appetite Modulation GLP-1 signaling also influences neural pathways involved in hunger and reward processing, as documented in clinical pharmacology research published in the NCBI [2] literature on incretin-based therapies

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Participants were randomized to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks

Blood sugar control shows dramatic improvement with both medications